Measuring how gadolinium-based contrast agents are distributed in the body after MRI scans
Quantification of whole-body distribution and speciation of gadolinium-based contrast agents by Y-86 PET/MRI
This study is looking at how gadolinium-based contrast agents used in MRI scans move and stay in the body, especially for patients with kidney problems, to help make these scans safer and more effective for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10928232 on NIH RePORTER |
What this research studies
This research investigates the distribution and retention of gadolinium-based contrast agents (GBCAs) used in MRI scans, which are essential for diagnosing various conditions like cancers and aneurysms. The study aims to understand how these agents behave in the body, particularly in patients with renal issues who may be at risk for complications. By utilizing advanced imaging techniques like Y-86 PET/MRI, the research seeks to quantify where gadolinium accumulates and how it is processed by the body. This could lead to improved safety and efficacy of GBCAs in clinical practice.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing MRI scans who have concerns about gadolinium retention, especially those with compromised kidney function.
Not a fit: Patients who have no history of MRI scans or those without any underlying health conditions related to gadolinium exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the safety of MRI procedures by providing insights into the risks associated with gadolinium retention in patients.
How similar studies have performed: Previous research has indicated potential risks associated with gadolinium retention, but this specific approach using Y-86 PET/MRI is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Le Fur, Mariane — Massachusetts General Hospital
- Study coordinator: Le Fur, Mariane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.