Measuring how brain tumor medicines reach and affect the brain
Analytical Immunopharmacology
This project builds lab tests and sampling methods to track how treatments for glioblastoma enter the brain and interact with tumors, helping doctors design better therapies for people with brain cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11184272 on NIH RePORTER |
What this research studies
From a patient's perspective: this core develops and runs lab methods to measure drug and immune therapy levels inside the brain, including using intracerebral microdialysis to collect brain fluid. It works directly with clinical teams running glioblastoma trials to plan and perform pharmacokinetic and pharmacodynamic sampling and to analyze drugs, metabolites, and immune markers. The team uses advanced analytical chemistry and immunochemistry instruments and shares results across the U19 projects to guide dosing, timing, and interpretation. Patients enrolled in linked clinical trials may be asked to provide samples or undergo monitoring so doctors can better understand how treatments behave in the central nervous system.
Who could benefit from this research
Good fit: Ideal candidates are people with glioblastoma or other brain tumors who are enrolled in the linked clinical trials and can consent to pharmacokinetic or biomarker sampling.
Not a fit: People without brain tumors or those not enrolled in the associated clinical trials would not directly benefit from the core's activities.
Why it matters
Potential benefit: If successful, this work could help doctors pick safer, more effective doses and schedules for brain tumor treatments.
How similar studies have performed: Similar brain pharmacokinetic and intracerebral microdialysis methods have been used previously, though combining these assays across multiple projects within a U19 network is relatively new.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Synold, Timothy W — Beckman Research Institute/city of Hope
- Study coordinator: Synold, Timothy W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.