Measuring hidden HIV reservoirs in the body
Official title: Centralized Resource to Accurately Quantify Latent and Expressed HIVReservoirs
Funded at Accelevir Diagnostics, LLC · NIH-11085352 · Data updated 2026-11-12
This study is looking at how HIV-1 can stay hidden in the body even when treatment is working well, and it aims to find better ways to get rid of these hidden infections, which could help people with HIV live healthier lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Accelevir Diagnostics, LLC NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 13, 2020 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $755,300 |
| NIH project number | 2R24AI143502-06 |
| Project ID | NIH-11085352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
✕Less likely to help
Patients who are not infected with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research focuses on understanding how HIV-1 persists in the body despite effective antiretroviral therapy. It aims to accurately quantify the latent and expressed reservoirs of HIV within CD4+ T cells, which are crucial for developing strategies to eliminate these hidden infections. By employing advanced assays and methodologies, the research seeks to identify the low-frequency latently infected cells that pose a barrier to curing HIV-1. Patients may benefit from improved treatment strategies that could lead to a functional cure for HIV.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate latent HIV reservoirs, potentially curing HIV infection.
How similar studies have gone: Previous research has shown promise in targeting latent HIV reservoirs, indicating that this approach has potential for success.
Where this research is happening
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Accelevir Diagnostics, LLC
Baltimore, United States Active
Researchers
- Principal investigator: Laird, Gregory Michael — Accelevir Diagnostics, LLC
- Study coordinator: Laird, Gregory Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.