Measuring Hepatitis B Virus Surface Antigen from Integrated DNA
Official title: Transcriptomic Quantitation of Hepatitis B Virus Surface Antigen from Integration
Funded at Saint Louis University · NIH-10840395 · Data updated 2026-11-12
This study is looking at how to better measure a specific marker of the Hepatitis B virus in people with chronic Hepatitis B, which can help doctors understand how well treatments are working and improve care for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 11, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $75,750 |
| NIH project number | 5R03AI178368-02 |
| Project ID | NIH-10840395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic Hepatitis B infection, particularly those who are HBeAg-negative.
✕Less likely to help
Patients with acute Hepatitis B infection or those who do not have detectable levels of HBsAg may not benefit from this research.
What this research studies
This research focuses on understanding the production of Hepatitis B virus surface antigen (HBsAg) in patients with chronic Hepatitis B infection. It aims to develop a novel method for quantitatively measuring HBsAg derived from integrated viral DNA, which is crucial for determining treatment outcomes. The approach involves advanced techniques such as quantitative reverse transcription PCR (qRT-PCR), digital droplet PCR (ddPCR), and next-generation sequencing (NGS) to enhance sensitivity and accuracy. By improving the measurement of HBsAg, the research seeks to provide better insights into the biological sources of this antigen and its implications for patient care.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with chronic Hepatitis B infection.
How similar studies have gone: While there have been advancements in measuring viral RNA in chronic Hepatitis B, this specific approach to quantifying HBsAg from integrated DNA is novel and has not been extensively tested.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Fan, Xiaofeng — Saint Louis University
- Study coordinator: Fan, Xiaofeng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.