Measuring Hepatitis B Virus Surface Antigen from Integrated DNA
Transcriptomic Quantitation of Hepatitis B Virus Surface Antigen from Integration
This study is looking at how to better measure a specific marker of the Hepatitis B virus in people with chronic Hepatitis B, which can help doctors understand how well treatments are working and improve care for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10840395 on NIH RePORTER |
What this research studies
This research focuses on understanding the production of Hepatitis B virus surface antigen (HBsAg) in patients with chronic Hepatitis B infection. It aims to develop a novel method for quantitatively measuring HBsAg derived from integrated viral DNA, which is crucial for determining treatment outcomes. The approach involves advanced techniques such as quantitative reverse transcription PCR (qRT-PCR), digital droplet PCR (ddPCR), and next-generation sequencing (NGS) to enhance sensitivity and accuracy. By improving the measurement of HBsAg, the research seeks to provide better insights into the biological sources of this antigen and its implications for patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic Hepatitis B infection, particularly those who are HBeAg-negative.
Not a fit: Patients with acute Hepatitis B infection or those who do not have detectable levels of HBsAg may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with chronic Hepatitis B infection.
How similar studies have performed: While there have been advancements in measuring viral RNA in chronic Hepatitis B, this specific approach to quantifying HBsAg from integrated DNA is novel and has not been extensively tested.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Fan, Xiaofeng — Saint Louis University
- Study coordinator: Fan, Xiaofeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.