Measuring eye pressure changes in healthy and high-pressure eyes
Official title: Measuring Ocular Pulse Amplitude with Fixed Force Applanation on Normotensive and Hypertensive Eyes
Funded at Duke University · NIH-11053858 · Data updated 2026-11-12
This study is looking at how the pressure inside your eye changes with your heartbeat to help doctors get a better idea of your eye health, especially if you're at risk for glaucoma or other eye conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $245,243 |
| NIH project number | 1R21EY036170-01A1 |
| Project ID | NIH-11053858 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with normal or elevated intraocular pressure, particularly those at risk for glaucoma or with conditions like diabetic retinopathy.
✕Less likely to help
Patients with no history of eye disease or those who do not have elevated intraocular pressure may not benefit from this research.
What this research studies
This research investigates the dynamic nature of intraocular pressure (IOP) in the eye, particularly how it fluctuates with the heartbeat. By measuring ocular pulse amplitude (OPA), which reflects these fluctuations, the study aims to improve the accuracy of IOP assessments, especially in patients at risk for glaucoma. The researchers will utilize advanced devices to capture these measurements, which could lead to better understanding and management of eye health. This approach may help identify patients with conditions like glaucoma, diabetic retinopathy, and age-related macular degeneration more effectively.
Why it matters
Potential benefit: If successful, this research could lead to more accurate assessments of eye pressure, improving early detection and treatment of glaucoma and other eye diseases.
How similar studies have gone: Previous studies have indicated the importance of ocular pulse amplitude in eye health, suggesting that this approach has potential based on preliminary findings.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Wen, Joanne — Duke University
- Study coordinator: Wen, Joanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.