Measuring energy production in pancreatic cancer cells
Official title: Quantitative Imaging of OXPHOS in Pancreatic Cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-10824274 · Data updated 2026-11-12
This study is looking at how pancreatic cancer cells use energy to grow and how this might help us find new treatments for patients with pancreatic cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 7, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $215,846 |
| NIH project number | 5R21CA280238-02 |
| Project ID | NIH-10824274 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma or those with high-risk precursor lesions.
✕Less likely to help
Patients with other types of cancer or those without pancreatic lesions may not benefit from this research.
What this research studies
This research investigates how pancreatic cancer cells produce energy through a process called oxidative phosphorylation (OXPHOS). Using advanced imaging techniques, specifically positron emission tomography (PET), the study aims to quantify OXPHOS activity in pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions. By examining genetically engineered mouse models, researchers will explore the relationship between OXPHOS activity and cancer progression, as well as the effects of OXPHOS inhibitors on survival. This approach could provide insights into potential new treatments for patients with pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for pancreatic cancer patients.
How similar studies have gone: While the specific application of PET imaging for OXPHOS in PDAC is novel, similar imaging techniques have shown promise in other cancer types.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Manning, Henry Charles — University of Tx Md Anderson Can Ctr
- Study coordinator: Manning, Henry Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.