Measuring early brain changes in Alzheimer's disease using MRI
Exploration of MRI measures of neurodegeneration within individuals over short intervals
This study is looking at new ways to spot early signs of Alzheimer's disease in people who might be at risk, using advanced brain scans to track changes over time, so we can help with earlier diagnosis and better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10818335 on NIH RePORTER |
What this research studies
This research investigates how to detect early signs of neurodegeneration in individuals at risk for Alzheimer's disease by utilizing advanced MRI imaging techniques. The approach focuses on making rapid and precise measurements of brain regions within the same person over short intervals, allowing for the tracking of changes that occur before noticeable cognitive decline. By differentiating between Alzheimer's and other forms of dementia, the study aims to enhance early diagnosis and monitoring of these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals in the early stages of Alzheimer's disease or those at high risk for developing the condition.
Not a fit: Patients with advanced Alzheimer's disease or other severe cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for tracking neurodegeneration, suggesting that this approach could yield significant insights.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Buckner, Randy L — Harvard University
- Study coordinator: Buckner, Randy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.