Measuring brain structure in fetuses using MRI
Measuring cortical plate and subplate thickness in the human fetal brain from magnetic resonance images
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10662526
This study is looking at how thick certain parts of a baby's brain are while they're still in the womb, using special MRI technology, to help us understand how brain development might affect learning and behavior later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10662526 on ClinicalTrials.gov |
What this research studies
This research focuses on analyzing the thickness of specific brain regions in fetuses, particularly the cortical plate and subplate, using advanced MRI techniques. By developing an automated method to accurately measure these regions, the study aims to enhance our understanding of fetal brain development and its implications for cognitive function and brain disorders. The research utilizes deep learning algorithms to improve the accuracy of MRI imaging, addressing challenges such as low resolution and motion artifacts that are common in fetal imaging. This work could lead to better insights into how brain structure relates to developmental outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals undergoing routine fetal MRI scans, particularly those at risk for developmental brain disorders.
Not a fit: Patients who are not pregnant or those whose fetuses are beyond the gestational age of 37 weeks may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into fetal brain development, potentially leading to early identification of brain disorders and improved outcomes for affected children.
How similar studies have performed: Previous research has shown success in using MRI to study postnatal brain development, but this approach for in utero measurements is relatively novel and untested.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IM, KIHO — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: IM, KIHO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.