Measuring brain oxygen metabolism in Alzheimer's disease using MRI
Official title: Quantitative MRI-based cerebral oxygen metabolism in Alzheimer's disease
Funded at Weill Medical Coll of Cornell Univ · NIH-10933507 · Data updated 2026-11-12
This study is testing a new MRI method to measure how well the brain uses oxygen in people with Alzheimer's disease, making it easier and safer to track changes in brain function over time without the need for expensive and radioactive tests.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $806,332 |
| NIH project number | 5R01AG080011-02 |
| Project ID | NIH-10933507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or mild cognitive impairment.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on developing a new MRI-based technique to measure cerebral oxygen metabolism in patients with Alzheimer's disease (AD). Current methods like PET scans are limited due to their use of radioactive tracers and higher costs, making them impractical for regular monitoring. The study aims to create a more accessible and accurate method for assessing brain metabolism, which could help in tracking disease progression and evaluating treatment effects. By using advanced MRI techniques, the researchers hope to provide a clearer picture of how Alzheimer's affects brain function over time.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and monitoring Alzheimer's disease, ultimately enhancing patient care.
How similar studies have gone: While MRI techniques have been explored in various contexts, this specific approach to measuring cerebral oxygen metabolism in Alzheimer's disease is novel and has not been extensively tested.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Wang, Yi — Weill Medical Coll of Cornell Univ
- Study coordinator: Wang, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.