Measuring brain oxygen levels after injury in newborns
CMRO2 and Uncoupling of Oxidative-Phosphorylation in Experimental HIE
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10918268
This study is looking at how brain injuries in newborns affect how their brains use oxygen, and it’s testing whether treatments like cooling and antioxidants can help improve their brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10918268 on ClinicalTrials.gov |
What this research studies
This research investigates how brain injuries in newborns affect oxygen metabolism using a non-invasive technique called photoacoustic microscopy. The study aims to understand the relationship between oxygen levels in the brain and mitochondrial function after a hypoxic-ischemic event. By examining mouse models, researchers will explore whether certain treatments, like hypothermia and antioxidants, can improve outcomes for brain injury. The findings could help identify effective therapies for protecting brain function in affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns and infants who have experienced hypoxic-ischemic brain injuries.
Not a fit: Patients who are older than 21 years or those without a history of brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for newborns suffering from brain injuries due to oxygen deprivation.
How similar studies have performed: Previous research has shown promise in using non-invasive methods to monitor brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUAN, CHIA-YI — UNIVERSITY OF VIRGINIA
- Study coordinator: KUAN, CHIA-YI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury