Measuring brain fluid circulation and choroid plexus function in Alzheimer's disease
Official title: Quantitative imaging of choroid plexus function and neurofluid circulation in Alzheimer's Disease Related Dementia
Funded at Vanderbilt University Medical Center · NIH-10914898 · Data updated 2026-11-12
This study is looking at new ways to take pictures of a part of the brain that helps produce fluid, to better understand how it works in people with Alzheimer's and related conditions, which could lead to improved ways to diagnose and treat these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $580,371 |
| NIH project number | 5R01AG083159-02 |
| Project ID | NIH-10914898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Alzheimer's Disease or related dementias.
✕Less likely to help
Patients who do not have Alzheimer's Disease or related dementias may not benefit from this research.
What this research studies
This research aims to develop advanced imaging techniques to non-invasively assess the choroid plexus, a critical structure in the brain responsible for producing cerebrospinal fluid. By utilizing magnetic resonance imaging and deep learning algorithms, the study will quantify choroid plexus activity and fluid flow in individuals with Alzheimer's Disease Related Dementias (ADRDs). The findings could help identify dysfunctions in fluid clearance mechanisms associated with neurodegenerative diseases, potentially leading to better diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Alzheimer's disease and improve diagnostic methods for patients with related dementias.
How similar studies have gone: Previous research has shown promising results using similar imaging techniques to study brain function in neurodegenerative disorders, indicating potential for success in this novel approach.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Donahue, Manus J — Vanderbilt University Medical Center
- Study coordinator: Donahue, Manus J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.