Measuring brain changes in Alzheimer's patients during treatment
Official title: Quantification of ARIA During the Treatment of Alzheimer's Patients
Funded at Cortechs Labs, INC. · NIH-10917839 · Data updated 2026-11-12
This study is looking at how a new Alzheimer's treatment called aducanumab affects the brain, using special MRI scans to help doctors spot any changes more easily, so they can better monitor patients and improve their care.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cortechs Labs, INC. NIH-funded |
| Lab location | 1 site (San Diego, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $295,759 |
| NIH project number | 1R44AG079694-01A1 |
| Project ID | NIH-10917839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Alzheimer's patients who are starting treatment with aducanumab or similar amyloid-targeting therapies.
✕Less likely to help
Patients who are not undergoing treatment with amyloid-clearing drugs or those with other forms of dementia may not benefit from this research.
What this research studies
This research focuses on detecting and quantifying changes in the brains of Alzheimer's patients who are receiving treatment with amyloid-clearing drugs, specifically aducanumab. Using advanced MRI imaging techniques, the study aims to develop software that can automatically identify and measure abnormalities related to the treatment, known as amyloid-related imaging abnormalities (ARIA). By improving the detection of these changes, the research seeks to enhance patient monitoring and treatment outcomes. The goal is to create a clinically usable tool that can assist healthcare providers in making informed decisions about patient care.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring of Alzheimer's patients during treatment, potentially improving their outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in using imaging techniques to monitor treatment effects in Alzheimer's patients, indicating that this approach could be effective.
Where this research is happening
-
Cortechs Labs, INC.
San Diego, United States Active
Researchers
- Principal investigator: Ulug, Aziz M — Cortechs Labs, INC.
- Study coordinator: Ulug, Aziz M
Related research
Other NIH-funded projects on the same topics.
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Measuring ARIA brain changes during Alzheimer’s antibody treatment
The project will build software that finds and measures ARIA — imaging changes like swelling or small bleeds — in people with Alzheimer’s who are getting amyloid‑clearing antibody therapy.
-
Using advanced imaging and AI to improve prostate cancer biopsy decisions
This study is working on new tools that use advanced imaging and artificial intelligence to help doctors better diagnose prostate cancer, making it easier to decide who needs a biopsy and where to focus on in the prostate.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.