Measuring brain blood vessel function to predict aging effects on the brain
Optical measures of cerebral arterial function as predictors of brain and cognitive aging
This study is looking at how stiff blood vessels in the brain might help us spot early signs of memory problems and Alzheimer's in older adults, using a special imaging technique that’s safe and non-invasive.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10394936 on NIH RePORTER |
What this research studies
This research investigates how changes in the function of blood vessels in the brain, particularly stiffness, can predict cognitive decline and conditions like Alzheimer's disease in older adults. Using a novel imaging technique called diffuse optical tomography, the study aims to map arterial health across the brain, providing a more comprehensive view than traditional methods. By identifying early signs of arterial stiffening, the research seeks to understand its relationship with age-related brain changes and cognitive decline. Participants may undergo non-invasive imaging to assess their cerebral arterial function and its implications for brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing cognitive changes or at risk for Alzheimer's disease.
Not a fit: Patients who are younger than 60 or do not have any cognitive concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early detection and intervention strategies for cognitive decline and Alzheimer's disease in older adults.
How similar studies have performed: Previous studies have shown that assessing cerebrovascular health can provide valuable insights into cognitive aging, suggesting that this approach may yield significant findings.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Fabiani, Monica — University of Illinois at Urbana-Champaign
- Study coordinator: Fabiani, Monica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.