Measuring blood flow in the heart using advanced imaging in mice
Quantitative MicroSPECT Imaging of Myocardial Blood Flow in Mice
This study is testing a new way to see how blood flows in the hearts of mice, which could help us learn more about heart diseases, especially those affecting small blood vessels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10663931 on NIH RePORTER |
What this research studies
This research focuses on developing a new imaging technique called microSPECT to measure blood flow in the heart of mice. By understanding how blood flows through the tiny vessels in the heart, researchers aim to gain insights into cardiovascular diseases, particularly coronary microvascular disease. The study will utilize specific tracers to visualize blood flow and validate these measurements against established methods. This approach allows for a better understanding of heart health and disease mechanisms in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with a family history of cardiovascular diseases or those exhibiting early signs of heart health issues.
Not a fit: Patients with advanced cardiovascular disease or those who are not genetically predisposed to microvascular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for assessing heart health and developing targeted therapies for cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in using imaging techniques to study blood flow in cardiovascular diseases, making this approach a continuation of established methodologies.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Metzler, Scott Dean — University of Pennsylvania
- Study coordinator: Metzler, Scott Dean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.