Measuring ARIA brain changes during Alzheimer’s antibody treatment
Quantification of ARIA During the Treatment of Alzheimer's Patients
['FUNDING_SBIR_2'] · CORTECHS LABS, INC. · NIH-11345590
The project will build software that finds and measures ARIA — imaging changes like swelling or small bleeds — in people with Alzheimer’s who are getting amyloid‑clearing antibody therapy.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORTECHS LABS, INC. (nih funded) |
| Locations | 1 site (San Diego, UNITED STATES) |
| Trial ID | NIH-11345590 on ClinicalTrials.gov |
What this research studies
If you have Alzheimer’s and are getting an amyloid‑clearing antibody such as aducanumab, this project will use MRI scans to find and quantify imaging abnormalities called ARIA (swelling or small bleeds) that can happen during treatment. The team will develop and validate computer software to detect and measure these ARIA lesions instead of relying only on visual reads by radiologists. They plan to test the software on MRIs taken before and during treatment and refine it so clinicians can use it in routine care. The goal is to make reporting of ARIA faster and more consistent to guide treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates are people with Alzheimer’s disease who are receiving or planning to receive amyloid‑lowering antibody treatments and who have MRI monitoring as part of their care or a clinical trial.
Not a fit: Patients not receiving amyloid‑clearing therapies or those without MRI scans are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the tool could detect ARIA earlier and more reliably, helping doctors make safer treatment decisions.
How similar studies have performed: Some automated MRI lesion tools exist and show promise, but automated, validated ARIA detection specifically for amyloid antibody therapy is still relatively new.
Where this research is happening
San Diego, UNITED STATES
- CORTECHS LABS, INC. — San Diego, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ULUG, AZIZ M — CORTECHS LABS, INC.
- Study coordinator: ULUG, AZIZ M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer disease treatment, Alzheimer syndrome