MCEMP1’s role in helping mast cells grow through the KIT receptor
MCEMP1 is an adaptor for KIT receptor for mast cell proliferation
['FUNDING_OTHER'] · CEDARS-SINAI MEDICAL CENTER · NIH-11304495
Finding out whether targeting the MCEMP1 protein can reduce mast cell growth and lung inflammation in people with asthma.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11304495 on ClinicalTrials.gov |
What this research studies
You would be hearing about work to understand a protein called MCEMP1 that is often higher in lungs during asthma flare-ups. Researchers will compare MCEMP1 levels in human asthma samples, study how MCEMP1 connects to the KIT receptor in lab-grown cells, and use mice lacking MCEMP1 to see how it changes mast cell growth and lung inflammation. The team will combine patient gene data, cell experiments, and animal models to see if blocking MCEMP1 reduces mast cell-driven airway problems. These steps aim to show whether MCEMP1 could become a target for future asthma treatments.
Who could benefit from this research
Good fit: People with asthma—especially those who have frequent or severe flare-ups—would be the most relevant candidates for related future studies or trials.
Not a fit: People without asthma or whose symptoms are clearly driven by non–mast-cell mechanisms are unlikely to benefit directly from this early research.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent mast cell-driven asthma flare-ups by targeting MCEMP1.
How similar studies have performed: This is a relatively new target: early animal and lab results suggest benefit, but human therapies aimed at MCEMP1 have not yet been tested.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOI, YOUN JUNG — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: CHOI, YOUN JUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease