Mayo Clinic proteomics center to find protein markers for multiple myeloma treatment response
Mayo Clinic Center for Clinical Proteomics
This project looks for protein markers in blood and bone marrow to help predict which people with multiple myeloma will respond to treatment.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11094724 on NIH RePORTER |
What this research studies
This effort brings together Mayo Clinic and Brigham Young University teams who will use mass spectrometry, genomics, and bioinformatics to search for proteins linked to treatment response in multiple myeloma. They will analyze patient blood and bone marrow samples taken before and after therapy, compare proteomic patterns across genetic subtypes, and identify candidate biomarkers. The center will develop and validate clinical protein tests and new instrument platforms to make findings usable in care. If you join a related trial or donate samples, your results could contribute to tests that predict resistance to common myeloma drugs.
Who could benefit from this research
Good fit: Ideal candidates are people with multiple myeloma—especially those starting or receiving immunomodulatory (IMiD) therapies or patients enrolled in Mayo Clinic clinical trials who can provide blood or bone marrow samples.
Not a fit: People without multiple myeloma or those who cannot or do not provide samples or participate in linked trials are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: Could help doctors choose more effective therapies and detect drug resistance earlier for people with multiple myeloma.
How similar studies have performed: Proteomic approaches have produced promising candidate markers in early studies, but validated clinical tests for treatment response in multiple myeloma remain limited.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Pandey, Akhilesh — Mayo Clinic Rochester
- Study coordinator: Pandey, Akhilesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.