Mavoglurant to reduce alcohol craving and heavy drinking
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11127638
This project looks at whether the medication mavoglurant can lower alcohol cravings and drinking in people who drink heavily.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11127638 on ClinicalTrials.gov |
What this research studies
If you take part, researchers will give the drug mavoglurant and track people’s alcohol craving and drinking behavior. The team is focusing on brain glutamate pathways that influence reward and habitual drinking to see how the medicine changes those signals. Mavoglurant is an oral drug that targets mGluR5 receptors and has shown safety and tolerability in prior work. The study connects animal and laboratory findings to direct clinical measures in heavy drinkers.
Who could benefit from this research
Good fit: Adults who are heavy drinkers or who meet criteria for alcohol use disorder and are willing to try a medication-based research protocol would be the best fit.
Not a fit: People who do not drink heavily, who are unwilling to take an experimental medication, or who have medical reasons that make mavoglurant unsafe may not benefit from this work.
Why it matters
Potential benefit: If successful, mavoglurant could help reduce cravings and drinking, making it easier for people to cut back or stay abstinent.
How similar studies have performed: Animal studies with mGluR5 blockers have reduced drinking and some early human data are suggestive, but clear clinical proof in heavy drinkers is still needed.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRISHNAN-SARIN, SUCHITRA — YALE UNIVERSITY
- Study coordinator: KRISHNAN-SARIN, SUCHITRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.