Mathematical Modeling to Improve Cardiac Resynchronization Therapy (CRT) Outcomes
Official title: Mathematical Model-Based Optimization of CRT Response in Ischemia
Funded at California Medical Innovations Institute · NIH-11380950 · Data updated 2026-11-12
A computer-modeling project aims to help doctors tailor CRT for heart failure patients to boost responder rates.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Medical Innovations Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $741,374 |
| NIH project number | 5R01HL166508-04 |
| Project ID | NIH-11380950 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with heart failure being considered for CRT, especially those with varying conduction delays and scar/ischemia patterns.
✕Less likely to help
Patients not eligible for CRT or without conduction disturbances related to heart failure may not benefit.
What this research studies
If you have heart failure and are considered for CRT, this project uses advanced computer simulations to understand how different pacing methods affect heart activation and timing. By combining machine learning with physics-based models, researchers will explore choices like conduction system pacing to see which approach works best for different patterns of heart damage. The goal is to identify personalized pacing strategies that improve short- and long-term heart function. Results could guide future clinical decisions and pave the way for smarter CRT treatments.
Why it matters
Potential benefit: If successful, the work could help more patients respond to CRT and experience better heart function and quality of life.
How similar studies have gone: Previous CRT optimization relied on clinical data; this project takes a novel computational approach that builds on prior modeling work but tests new combinations like CSP.
Where this research is happening
-
California Medical Innovations Institute
San Diego, United States Active
Researchers
- Principal investigator: Kassab, Ghassan S — California Medical Innovations Institute
- Study coordinator: Kassab, Ghassan S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.