Materials that control healing proteins to help bones repair
Modulating Protein Activity in Tissue Repair using Engineered Affinity-based Biomaterials
['FUNDING_OTHER'] · UNIVERSITY OF OREGON · NIH-11325700
This project develops engineered materials that control when and how healing proteins are released to help bones recover after injury.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-11325700 on ClinicalTrials.gov |
What this research studies
This work creates affinity-based biomaterials that can hold and then release multiple healing proteins in a controlled way at a bone injury site. The team will tune how strongly different proteins bind the material so timing and local concentration can be changed, and they will test effects on cells and tissue using lab experiments and computer models. Results will show which protein combinations and release schedules best support bone regeneration and how materials can be adjusted for complex healing needs. The research is being done in the PI's lab as a step toward materials that could enter future patient trials.
Who could benefit from this research
Good fit: People with bone fractures or other bone injuries that heal slowly or poorly could be candidates for future trials of these biomaterials.
Not a fit: This is a basic research project, so patients needing immediate treatment or those with conditions unrelated to bone repair should not expect direct benefit now.
Why it matters
Potential benefit: If successful, these materials could lead to implants or therapies that deliver the right mix of proteins at the right times to speed and improve bone healing.
How similar studies have performed: Related affinity-based biomaterials have shown promise in lab and animal studies, but independently controlling multiple proteins for bone repair is a newer approach with limited prior clinical testing.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HETTIARATCHI, MARIAN HIRUSHIKA — UNIVERSITY OF OREGON
- Study coordinator: HETTIARATCHI, MARIAN HIRUSHIKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Injury