Matching blood transfusions for sickle cell disease patients based on their Rh genotype
RH genotype matched red cell transfusions for patients with sickle cell disease
This study is looking to make blood transfusions safer for people with sickle cell disease by matching their blood type more closely with donors, which could help prevent problems with their immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10470880 on NIH RePORTER |
What this research studies
This research focuses on improving blood transfusions for patients with sickle cell disease (SCD) by matching the Rh genotype of donors and recipients. The study aims to reduce the risk of alloimmunization, which is the formation of antibodies against transfused red blood cells, a common issue for SCD patients. By using DNA-based matching to identify compatible blood donors, the research seeks to enhance the safety and effectiveness of transfusions. The project will conduct pilot clinical studies to assess the feasibility of providing genetically matched red blood cells to patients who require regular transfusions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with sickle cell disease who require regular blood transfusions.
Not a fit: Patients who do not have sickle cell disease or those who do not require blood transfusions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the safety and efficacy of blood transfusions for patients with sickle cell disease.
How similar studies have performed: Previous studies have indicated that genetic matching can reduce alloimmunization rates, suggesting potential success for this novel approach.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Chou, Stella T — Children's Hosp of Philadelphia
- Study coordinator: Chou, Stella T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.