Mapping variations in natural killer cell receptors in diverse human populations
Official title: Defining Variation in the Natural Killer Cell Receptome in Human Populations
Funded at University of North Carolina Charlotte · NIH-10877089 · Data updated 2026-11-12
This study is looking at the differences in immune system cells called natural killer (NK) cells, which help fight infections and cancer, by examining DNA from over 2,150 people from different backgrounds, including African Americans and Native Americans, to better understand how these differences can affect health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project start | August 18, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $193,250 |
| NIH project number | 5R21HG012386-03 |
| Project ID | NIH-10877089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse ancestral backgrounds, particularly those who identify as African American or Native American.
✕Less likely to help
Patients who do not belong to the studied ancestral groups or those with conditions unrelated to immune response may not benefit from this research.
What this research studies
This research aims to create a detailed map of the variations in natural killer (NK) cell receptors, which play a crucial role in the immune response against infections and cancer. By sequencing DNA from over 2,150 individuals across various ancestries, including African Americans and Native Americans, the study will analyze the genetic differences in NK cell receptors. The researchers will utilize advanced next-generation sequencing techniques and custom bioinformatics tools to identify structural variations and their implications for immune function.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses in different populations, potentially leading to improved treatments for infections and cancers.
How similar studies have gone: Previous research has shown promise in mapping genetic variations related to immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of North Carolina Charlotte
Charlotte, United States Active
Researchers
- Principal investigator: Augusto, Danillo G — University of North Carolina Charlotte
- Study coordinator: Augusto, Danillo G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.