Mapping the superficial white matter in the primate brain
Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography Validation
This study is looking at how different parts of the brain connect with each other in monkeys, which will help improve brain scans for understanding conditions like autism and Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10865069 on NIH RePORTER |
What this research studies
This research investigates the superficial white matter (SWM) in the primate brain, specifically focusing on how it connects different areas of the cerebral cortex. By using advanced imaging techniques and experimental methods, the study aims to create a detailed map of the SWM in rhesus macaque monkeys. This mapping will help validate diffusion MRI (dMRI) techniques, which are used to visualize brain connections in living subjects. Understanding the SWM is crucial for interpreting brain imaging results, especially in relation to neurological conditions like autism and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals diagnosed with autism spectrum disorder or Alzheimer's disease.
Not a fit: Patients with conditions unrelated to the neurological connections studied, or those not diagnosed with autism or Alzheimer's, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain connectivity and improve diagnostic and treatment approaches for neurological conditions.
How similar studies have performed: Other research has shown success in using similar imaging techniques to map brain structures, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Rushmore, Richard Jarrett — Boston University Medical Campus
- Study coordinator: Rushmore, Richard Jarrett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.