Mapping the structure and function of the small bowel and colon in 3D
Comparing transcriptional and protein-based approaches in 3D tissue altasing
This study is exploring the tiny details of the small intestine and colon to better understand how they work and what goes wrong in diseases, using advanced mapping techniques on tissue samples from organ donors, and it aims to help researchers improve gut health for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11089006 on NIH RePORTER |
What this research studies
This research investigates the complex structure and function of the small bowel and colon by creating detailed three-dimensional maps at the single-cell level. It utilizes advanced techniques such as single-nuclei ATAC-seq and RNA-seq to analyze tissue samples collected from deceased organ donors. The study aims to integrate these molecular profiles with spatial mapping technologies to enhance our understanding of intestinal health and disease. By providing a community resource, it seeks to facilitate further research into gastrointestinal function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal conditions or those interested in the biological mechanisms of the small bowel and colon.
Not a fit: Patients with acute gastrointestinal issues requiring immediate clinical intervention may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of intestinal diseases, enhancing patient care.
How similar studies have performed: Previous research has shown success in using similar multi-modal mapping approaches to study complex biological systems, indicating potential for impactful findings in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Snyder, Michael P. — Stanford University
- Study coordinator: Snyder, Michael P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.