Mapping the structure and connections of brain cells
Comprehensive and multi-resolution mapping of cell morphology and wiring through X-ray holographic nano-tomography
This study is looking at how brain cells work together, especially in an area called the cerebellum that helps with movement and social skills, to help us learn more about brain disorders and improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10376584 on NIH RePORTER |
What this research studies
This research aims to understand how information is processed in the brain by mapping the complex networks of neurons, particularly in the cerebellum, which is crucial for motor control and social behavior. Using advanced imaging techniques like X-ray holographic nano-tomography, the project will create detailed maps of neuronal types and their connections. This comprehensive characterization will help to reverse engineer functional neural circuits, providing insights into how brain cells interact and function together. Patients may benefit from a better understanding of neurological disorders through this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological disorders or those interested in brain health.
Not a fit: Patients with conditions unrelated to neurological function or those not residing in the research area may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating neurological disorders.
How similar studies have performed: Other research has shown success in mapping brain structures using advanced imaging techniques, indicating a promising approach.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Lee, Wei-Chung Allen — Harvard Medical School
- Study coordinator: Lee, Wei-Chung Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.