Mapping the role of long noncoding RNAs in intestinal health
Spatial subcellular mapping of the intestinal LncRNAome
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11014345
This study is looking at how certain molecules in our cells, called long noncoding RNAs, might affect ulcerative colitis, with the hope of finding new ways to improve treatment for people living with this condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11014345 on ClinicalTrials.gov |
What this research studies
This research investigates the role of long noncoding RNAs (lncRNAs) in the development and progression of ulcerative colitis (UC), a chronic inflammatory bowel disease. By examining how these lncRNAs interact with cellular structures and metabolic pathways in the intestines, the study aims to uncover new regulatory factors that could improve treatment options. The research utilizes advanced techniques to map the localization and function of lncRNAs within colonic cells, potentially leading to novel therapeutic targets for UC. Patients may benefit from a deeper understanding of their condition and new treatment strategies that arise from these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ulcerative colitis who are seeking new treatment options.
Not a fit: Patients with other gastrointestinal disorders unrelated to ulcerative colitis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better manage or even reverse the effects of ulcerative colitis.
How similar studies have performed: While the role of lncRNAs in chronic diseases is an emerging field, this specific approach to mapping their function in ulcerative colitis is relatively novel and has not been extensively tested.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALIA, LIRAZ — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: GALIA, LIRAZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.