Mapping the role of long noncoding RNAs in intestinal health
Official title: Spatial subcellular mapping of the intestinal LncRNAome
Funded at Ut Southwestern Medical Center · NIH-11014345 · Data updated 2026-11-12
This study is looking at how certain molecules in our cells, called long noncoding RNAs, might affect ulcerative colitis, with the hope of finding new ways to improve treatment for people living with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 23, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $492,000 |
| NIH project number | 5DP2AI177910-02 |
| Project ID | NIH-11014345 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ulcerative colitis who are seeking new treatment options.
✕Less likely to help
Patients with other gastrointestinal disorders unrelated to ulcerative colitis may not receive any benefit from this research.
What this research studies
This research investigates the role of long noncoding RNAs (lncRNAs) in the development and progression of ulcerative colitis (UC), a chronic inflammatory bowel disease. By examining how these lncRNAs interact with cellular structures and metabolic pathways in the intestines, the study aims to uncover new regulatory factors that could improve treatment options. The research utilizes advanced techniques to map the localization and function of lncRNAs within colonic cells, potentially leading to novel therapeutic targets for UC. Patients may benefit from a deeper understanding of their condition and new treatment strategies that arise from these findings.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better manage or even reverse the effects of ulcerative colitis.
How similar studies have gone: While the role of lncRNAs in chronic diseases is an emerging field, this specific approach to mapping their function in ulcerative colitis is relatively novel and has not been extensively tested.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Galia, Liraz — Ut Southwestern Medical Center
- Study coordinator: Galia, Liraz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.