Mapping the proteins in aging cells and their surroundings at a single-cell level
Spatially-resolved proteome mapping of senescent cells and their tissue microenvironment at single-cell resolution
['FUNDING_OTHER'] · BATTELLE PACIFIC NORTHWEST LABORATORIES · NIH-10684865
This study is looking at special cells that stop growing because of stress, which are connected to aging and diseases like cancer and diabetes, to find unique markers that could help us understand how they affect our health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BATTELLE PACIFIC NORTHWEST LABORATORIES (nih funded) |
| Locations | 1 site (RICHLAND, UNITED STATES) |
| Trial ID | NIH-10684865 on ClinicalTrials.gov |
What this research studies
This research investigates the characteristics of senescent cells, which are cells that have stopped dividing due to stress and are linked to various aging-related diseases. By using advanced techniques like mass spectrometry and microfluidics, the study aims to identify unique protein markers in these cells and their environment. This could lead to a better understanding of how these cells contribute to conditions such as cancer and diabetes. The research will involve isolating and analyzing individual cells from human and mouse tissues to create a detailed map of cellular senescence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing aging-related conditions, such as cancer, osteoarthritis, or type 2 diabetes.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies targeting senescent cells, potentially improving outcomes for patients with aging-related diseases.
How similar studies have performed: Previous research has shown promise in using proteomics to study cellular senescence, indicating that this approach could yield valuable insights.
Where this research is happening
RICHLAND, UNITED STATES
- BATTELLE PACIFIC NORTHWEST LABORATORIES — RICHLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PASA-TOLIC, LJILJANA — BATTELLE PACIFIC NORTHWEST LABORATORIES
- Study coordinator: PASA-TOLIC, LJILJANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer