Mapping the protein networks that drive cancer
Project 1: Systematic Physical and Spatial Mapping of Cancer Driver Networks
This project builds detailed maps of how genes and proteins interact across different tumors to help find new targets for cancer treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11169867 on NIH RePORTER |
What this research studies
This effort combines tumor genomic data with protein-level and spatial measurements to chart how cancer driver pathways are wired in individual tumors and across cancer types. Researchers will use large-scale proteomics, imaging and high-resolution structural methods to identify physical interactions and where proteins sit in tumor tissue. The team integrates those maps with existing genetic data to reveal converging pathways that may be missed by looking at mutations alone. Work will rely on patient-derived tumor samples and shared datasets to create resources that clinicians and researchers can use.
Who could benefit from this research
Good fit: People with cancer who can provide tumor tissue or agree to let their tumor genomic or proteomic data be used for research would be the best fit.
Not a fit: Patients seeking an immediate new treatment are unlikely to benefit directly, since this is a research mapping project rather than a therapeutic trial.
Why it matters
Potential benefit: If successful, the maps could point to new drug targets and biomarkers that guide more precise cancer treatments.
How similar studies have performed: Previous genomic and network-mapping projects have identified key cancer pathways, but this large-scale integration of spatial proteomics and structural mapping is a newer and less-tested approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Lundberg, Emma — University of California, San Francisco
- Study coordinator: Lundberg, Emma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.