Mapping the progression of pancreatic tumors in high-risk individuals
Official title: An atlas of pancreatic tumorigenesis in the context of altered DNA repair occurring in high-risk individuals
Funded at Oregon Health & Science University · NIH-10995215 · Data updated 2026-11-12
This study is working to create a 3D map of how pancreatic tumors develop, especially for people with certain genetic traits like BRCA mutations, to help spot early signs of cancer and improve detection methods.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,035,138 |
| NIH project number | 1U01CA294548-01 |
| Project ID | NIH-10995215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of pancreatic cancer or those carrying pathogenic variants in BRCA1 or BRCA2 genes.
✕Less likely to help
Patients without a genetic predisposition to pancreatic cancer or those diagnosed with advanced-stage pancreatic cancer may not benefit from this research.
What this research studies
This research aims to create a detailed 3D atlas that illustrates the progression of pancreatic tumors, specifically focusing on individuals with genetic predispositions such as BRCA mutations. By examining the early stages of pancreatic cancer development, the project seeks to identify critical changes that occur as benign lesions transform into malignant tumors. The approach involves advanced bioinformatics and 3D modeling techniques to visualize and analyze these cellular changes, which could lead to improved early detection strategies for pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of pancreatic cancer, significantly improving survival rates for high-risk patients.
How similar studies have gone: Previous research has shown promise in using 3D modeling and molecular atlases to understand cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Sears, Rosalie C — Oregon Health & Science University
- Study coordinator: Sears, Rosalie C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.