Mapping the movements of genes and chromatin in living cells
In vivo spatiotemporal mapping of genome-wide motions and gene-level transcriptional activity via integrated experimental platform and data-analytical pipeline
This study is exploring how our genes and the material that helps organize them move and work inside our cells, using cutting-edge technology to help scientists see these actions in real time, which could lead to a better understanding of how our cells function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11073015 on NIH RePORTER |
What this research studies
This research investigates how the human genome moves and functions within cells by mapping the dynamics of chromatin and gene activity in real time. Using advanced techniques from molecular biology and physics, the study aims to create a platform that allows researchers to observe the motions of genes and chromatin across the nucleus of living mammalian cells. By integrating machine learning algorithms with innovative imaging methods, the project seeks to uncover the relationship between local gene activity and broader chromatin movements, providing insights into fundamental cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or cancers that may be influenced by chromatin dynamics and gene expression.
Not a fit: Patients with stable, non-genetic conditions or those not affected by chromatin-related processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation and chromatin dynamics, potentially leading to new therapeutic strategies for various diseases, including cancers.
How similar studies have performed: While the specific approach of integrating real-time chromatin mapping with gene activity monitoring is novel, similar studies have shown promise in understanding gene regulation and cellular dynamics.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Zidovska, Alexandra — New York University
- Study coordinator: Zidovska, Alexandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.