Mapping the molecular structure of heart cell connections
Molecular Atlas of the Cardiac Intercalated Disc
This study is looking at how tiny parts of heart cells work together to keep your heart beating properly, especially in people with certain genetic changes that can cause heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11004643 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that regulate the electrical activity of heart cells, specifically focusing on the cardiac intercalated disc, which is crucial for heart function. By using advanced techniques like proteomics and genomics, the study aims to create a detailed map of this structure and understand how it contributes to heart rhythm and excitability. The research will involve examining both normal hearts and those with mutations in a specific protein that can lead to dangerous heart conditions. This comprehensive approach seeks to fill the knowledge gaps regarding the molecular composition and functions of the intercalated disc.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with known heart rhythm issues or genetic mutations affecting heart function.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of heart rhythm disorders, potentially saving lives.
How similar studies have performed: Other research has shown success in understanding cardiac structures and their roles in heart function, making this approach promising.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Delmar, Mario — New York University School of Medicine
- Study coordinator: Delmar, Mario
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.