Mapping the molecular profiles of every cell type in the human brain
High-content single-cell epigenetic technologies scalable to the human brain
This study is working to map out the different types of cells in the human brain to help us understand how they function and how they might be involved in brain-related conditions, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10369335 on NIH RePORTER |
What this research studies
This research aims to create a detailed catalog of molecular profiles for every cell type in the human brain by developing advanced techniques that significantly improve the analysis of single cells. It utilizes innovative chemistry workflows and combinatorial indexing methods to enhance the coverage and throughput of DNA and RNA profiling. Patients may benefit from this research as it could lead to a better understanding of brain cell functions and their roles in neurological conditions. The project will also produce an atlas of epigenetic profiles in specific brain regions, which could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological conditions or those interested in brain health.
Not a fit: Patients with conditions unrelated to brain function or those not residing in the geographic area of the research may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into brain cell functions and contribute to advancements in treating neurological disorders.
How similar studies have performed: Other research has shown success in similar approaches, particularly in the field of single-cell genomics and epigenetics, indicating a promising avenue for this project.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Adey, Andrew — Oregon Health & Science University
- Study coordinator: Adey, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.