Mapping the molecular features of healthy and diseased pediatric kidneys
Research Project 1: A Multidimensional Molecular Atlas of Healthy and Diseased Human Pediatric Kidney
This study is looking at kidney samples from healthy and sick kids to better understand how their kidneys work and what causes kidney diseases, with the hope of improving how we diagnose and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10915731 on NIH RePORTER |
What this research studies
This research aims to create a detailed molecular atlas of both healthy and diseased kidneys in children. By utilizing advanced techniques like single-nucleus RNA sequencing and ATAC sequencing, the project will analyze kidney samples to understand how various factors affect kidney development and function. The goal is to gather critical data that can help identify the causes and consequences of kidney diseases in children, ultimately improving diagnosis and treatment options. This collaborative effort involves a network of investigators and aims to include diverse pediatric samples to ensure comprehensive insights.
Who could benefit from this research
Good fit: Ideal candidates for this research include children with congenital kidney anomalies, glomerular diseases, or those who have experienced acute kidney injury.
Not a fit: Patients with kidney diseases unrelated to developmental or congenital issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of kidney diseases in children, potentially reducing disability and mortality rates.
How similar studies have performed: Other research has successfully utilized similar molecular mapping techniques in adult populations, but this specific focus on pediatric kidneys is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Jain, Sanjay — Washington University
- Study coordinator: Jain, Sanjay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.