Mapping the molecular changes in Alzheimer's disease at the single-cell level
3D spatial single-cell multiomics mapping of Alzheimer's disease
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10939938
This study is looking at how Alzheimer's disease affects brain cells by using a special technique to safely examine tiny parts of these cells, helping researchers understand the changes that happen in the disease and potentially leading to better treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10939938 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular changes associated with Alzheimer's disease by using a novel technique called Gel-based Optical-isolation 3D (GO3D) multiomics. This method allows researchers to analyze tiny projections of brain cells, specifically astrocytes, without damaging them, which is crucial for understanding the disease's progression. By identifying proteins and their modifications in these cells, the research aims to create a detailed multiomics map of Alzheimer's disease. This approach combines mass spectrometry and next-generation sequencing to provide insights into the molecular mechanisms underlying Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those interested in contributing to advancements in understanding the disease.
Not a fit: Patients with early-stage cognitive impairment or those not diagnosed with Alzheimer's disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease and potentially identify new therapeutic targets.
How similar studies have performed: Other research has shown success in using advanced single-cell sequencing techniques to study Alzheimer's, but the specific approach of GO3D multiomics is relatively novel.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, XIAOYU — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SHI, XIAOYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease