Mapping the interactions of the androgen receptor to understand hormone signaling
Construction of the Androgen Receptor Interactome: A Molecular Framework for Probing Genetic Interactions in Androgen-Dependent Signaling
This study is looking at how a specific hormone receptor in your body interacts with different proteins, which could help us understand how hormone signaling works and improve our knowledge of related health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10878778 on NIH RePORTER |
What this research studies
This research focuses on the androgen receptor, a key hormone receptor that influences various bodily functions. By identifying and characterizing the proteins that interact with the androgen receptor, researchers aim to create a detailed map of these interactions, known as the AR-interactome. This mapping will help clarify how these proteins work together to regulate hormone signaling in cells. The study employs advanced biochemical techniques to analyze these interactions in a controlled cellular environment, which could lead to better understanding of conditions influenced by androgen signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by androgen signaling, such as prostate cancer or androgen insensitivity syndrome.
Not a fit: Patients with conditions unrelated to androgen signaling or those who do not have any hormonal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases related to androgen signaling, such as prostate cancer and other hormone-related disorders.
How similar studies have performed: Previous research has successfully mapped protein interactions in other hormone signaling pathways, suggesting that this approach could yield valuable insights into androgen receptor function as well.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Wright, Michael E — University of Iowa
- Study coordinator: Wright, Michael E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.