Mapping the human immune response to peanut allergies
Comprehensive antigenic mapping of the human anti-peanut IgE antibody response
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10991346
This study is looking at how the immune system reacts to peanut allergies by focusing on a special antibody called IgE, and it's for people with peanut allergies who want to understand more about why their bodies react the way they do.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10991346 on ClinicalTrials.gov |
What this research studies
This research investigates how the human immune system responds to peanut allergens by focusing on a specific type of antibody called IgE. It aims to create a detailed map of the interactions between IgE and peanut proteins, which can trigger severe allergic reactions. By isolating and studying naturally occurring IgE antibodies from individuals with peanut allergies, the researchers hope to better understand the mechanisms behind allergic responses and anaphylaxis. This approach involves advanced techniques to grow and identify specific immune cells that produce these antibodies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a diagnosed peanut allergy and have experienced allergic reactions.
Not a fit: Patients without a peanut allergy or those who have not experienced allergic reactions to peanuts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for individuals with peanut allergies.
How similar studies have performed: While studies on IgE and allergies have been conducted, this specific approach using human monoclonal antibodies is novel and has not been extensively tested before.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, SCOTT ALAN — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: SMITH, SCOTT ALAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease