Mapping the genetics of snails that spread schistosomiasis
Official title: Fine-resolution genetic mapping of advanced intercross lines of Biomphalaria glabrata
Funded at University of New Mexico · NIH-11210221 · Data updated 2026-11-12
This study is looking at the genes of a type of snail that spreads a disease called schistosomiasis, to find out how their genetics influence how many infectious parasites they produce, which could help us find better ways to control the disease by focusing on the snails instead of just treating people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | June 18, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $430,251 |
| NIH project number | 1R21AI193098-01 |
| Project ID | NIH-11210221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals living in regions where schistosomiasis is endemic, particularly those at risk of infection.
✕Less likely to help
Patients who are not affected by schistosomiasis or do not live in areas where the disease is prevalent may not benefit from this research.
What this research studies
This research investigates the genetic makeup of Biomphalaria glabrata, a type of snail that carries the schistosomiasis-causing parasite. By creating advanced intercross lines of these snails, the study aims to understand how different genetic traits affect their ability to produce cercariae, the infectious stage of the parasite. This could lead to new methods for controlling the spread of schistosomiasis by targeting the snails themselves, rather than just treating the disease in humans. The research employs genetic mapping techniques to identify specific genes associated with resistance to the parasite.
Why it matters
Potential benefit: If successful, this research could lead to innovative strategies for controlling schistosomiasis, potentially reducing infection rates in humans.
How similar studies have gone: While the approach of using genetic biocontrol in snails is innovative, similar genetic mapping strategies have shown promise in other vector control studies, indicating potential for success.
Where this research is happening
-
University of New Mexico
Albuquerque, United States Active
Researchers
- Principal investigator: Zhang, Si-Ming — University of New Mexico
- Study coordinator: Zhang, Si-Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.