Mapping the genetic elements that regulate insulin-producing cells in diabetes
Discovery of diabetes-relevant ò cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screens
This study is looking at how certain genes help control insulin-producing cells in the pancreas, especially in people with type 2 diabetes, to find new ways to treat the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10902104 on NIH RePORTER |
What this research studies
This research investigates the role of specific genetic enhancers in the regulation of insulin-producing beta cells, particularly in the context of type 2 diabetes. By utilizing advanced techniques to analyze the three-dimensional structure of DNA, the researchers aim to identify how these enhancers function and change in healthy versus diabetic conditions. The study involves comparing human pancreatic islets from healthy individuals and those with diabetes, as well as examining early developmental stages of beta cells derived from stem cells. This comprehensive approach seeks to uncover critical genetic factors that could lead to new therapeutic strategies for diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes or those interested in the genetic factors influencing beta cell function.
Not a fit: Patients with type 1 diabetes or other forms of diabetes unrelated to beta cell function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for type 2 diabetes by enhancing our understanding of beta cell function and regulation.
How similar studies have performed: Previous research has shown promise in understanding enhancer functions in other contexts, but this specific approach to mapping 3D enhancer networks in diabetes is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Huangfu, Danwei — Sloan-Kettering Inst Can Research
- Study coordinator: Huangfu, Danwei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.