Mapping the genetic effects of Down syndrome on organ development
Trisomy 21 Model Atlas
This study is looking at how Down syndrome affects the way genes work in different parts of the body, using mice and special human cells, to help us understand more about the condition and find better ways to support people with it, including those at risk for Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10930970 on NIH RePORTER |
What this research studies
This research investigates how trisomy 21, the genetic cause of Down syndrome, affects gene expression in various tissues and organs. By using mouse models and human induced pluripotent stem cells, the study aims to create a comprehensive atlas that details how these genetic changes influence organ development and contribute to associated health conditions like Alzheimer's disease. Patients can benefit from insights gained about the underlying mechanisms of their condition, which may lead to improved treatments and care strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Down syndrome, particularly those experiencing co-occurring conditions such as Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who do not have related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of health issues associated with Down syndrome.
How similar studies have performed: Previous research using similar models has shown promise in understanding genetic conditions, indicating potential for success in this novel approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Galbraith, Matthew D — University of Colorado Denver
- Study coordinator: Galbraith, Matthew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.