Mapping the genetic and protein landscape of cancer tissues at a cellular level
Official title: Spatially resolved multi-omics sequencing of FFPE tissues at cellular level
Funded at University of Pennsylvania · NIH-10915826 · Data updated 2026-11-12
This study is looking at how cancer tumors work with nearby healthy cells by examining old tissue samples, with the goal of creating new tools that could help doctors understand cancer better and improve treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $227,906 |
| NIH project number | 1R61CA287408-01A1 |
| Project ID | NIH-10915826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with archived FFPE cancer tissue samples available for analysis.
✕Less likely to help
Patients without archived FFPE samples or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research focuses on understanding how tumors interact with surrounding non-cancer cells by analyzing archived cancer tissue samples. It aims to develop a new technology that allows for detailed mapping of the epigenome, transcriptome, and proteins within these tissues at the cellular level. By utilizing formalin-fixed paraffin-embedded (FFPE) samples, the study will explore the complex relationships within tumors, potentially leading to better diagnosis and treatment options for various cancer subtypes. Patients may benefit from advancements in personalized cancer therapies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted treatments for specific cancer subtypes.
How similar studies have gone: Other research has shown promise in using spatial omics technologies for cancer analysis, indicating potential success for this novel approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Deng, Yanxiang — University of Pennsylvania
- Study coordinator: Deng, Yanxiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.