Mapping the genes involved in chronic pain
Multi-omics peripheral nerve atlas enables fine-mapping of pain molecular phenotypes
This study is looking at the genes that might cause chronic pain in people with unexplained nerve pain, and it aims to better understand how different nerve cells work together, which could help find new ways to treat pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10930005 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to chronic pain by analyzing the genomes of patients suffering from idiopathic painful neuropathy. Using advanced techniques like single-nuclei RNA sequencing, the team aims to create a detailed atlas of human peripheral nerve cells, including nociceptive neurons and supporting cells like glia and macrophages. By understanding how these cells interact and contribute to pain, the research seeks to bridge the gap between human pain mechanisms and existing preclinical models. This could lead to the identification of new therapeutic targets for chronic pain management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from idiopathic painful neuropathy.
Not a fit: Patients with chronic pain conditions unrelated to neuropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for chronic pain, reducing reliance on opioids.
How similar studies have performed: Other research has shown promise in using genomic approaches to understand pain mechanisms, but this specific multi-omics approach is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Milbrandt, Jeffrey D — Washington University
- Study coordinator: Milbrandt, Jeffrey D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.