Mapping the genes and cells of the human ureter and bladder throughout life
High resolution transcriptome and gene regulatory mapping of human ureter and bladder across the lifespan
This study is looking at the cells and genes in the ureter and bladder from people of different ages, both healthy and those with conditions, to help us better understand urinary tract issues and find new ways to treat them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10899564 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular makeup of the human ureter and bladder across different ages, focusing on both healthy and diseased states. By collecting tissue samples from organ donors, the study aims to create a detailed map of gene activity and cell types in these organs. This will involve advanced techniques like single-cell RNA sequencing and spatial transcriptomics to analyze tissues from various anatomical locations. The goal is to enhance our understanding of lower urinary tract conditions and potentially guide the development of new treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with benign urologic diseases or those interested in the health of their lower urinary tract, particularly across different age groups.
Not a fit: Patients with acute or severe urologic conditions requiring immediate intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for common urologic conditions affecting the bladder and ureter.
How similar studies have performed: Other research has shown promise in using similar high-resolution mapping techniques to understand complex tissues, indicating potential for success in this approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Wessely, Oliver — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Wessely, Oliver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.