Mapping the evolution of hereditary diffuse gastric cancer
Official title: Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D)
Funded at University of Tx Md Anderson Can Ctr · NIH-10994921 · Data updated 2026-11-12
This study is looking at how certain gene changes can lead to stomach cancer in families, and it aims to find early signs of cancer using new technology, so that patients can get the right treatment and avoid unnecessary surgeries.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,069,873 |
| NIH project number | 1U01CA294518-01 |
| Project ID | NIH-10994921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with pathogenic CDH1 mutations or those with a family history of hereditary diffuse gastric cancer.
✕Less likely to help
Patients without CDH1 mutations or those not at risk for hereditary diffuse gastric cancer may not benefit from this research.
What this research studies
This research focuses on understanding hereditary diffuse gastric cancer (HDGC) linked to CDH1 gene mutations, which significantly increase the risk of developing advanced gastric cancer. By utilizing advanced 3D analysis and artificial intelligence, the project aims to identify early precancerous lesions and better stratify patients based on their risk of progression to cancer. This could lead to more personalized treatment approaches, potentially reducing unnecessary surgeries for patients who may not need them. The study will analyze patient data to create a comprehensive atlas of disease progression.
Why it matters
Potential benefit: If successful, this research could lead to improved early diagnosis and personalized treatment strategies for patients at risk of hereditary diffuse gastric cancer.
How similar studies have gone: Previous research has shown promise in using advanced imaging and genetic analysis to improve cancer risk assessment, indicating that this approach could yield significant insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Wang, Linghua — University of Tx Md Anderson Can Ctr
- Study coordinator: Wang, Linghua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.