Mapping the environment of aging cells in tissues
Spatial omics technologies to map the senescent cell microenvironment
This study is looking at how aging cells impact the tissues around them, with the goal of finding better ways to treat age-related diseases and improve cancer therapies, so patients can have more effective options for managing their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10915720 on NIH RePORTER |
What this research studies
This research investigates how aging cells, known as senescent cells, affect their surrounding environment in various tissues. By developing advanced technologies, the project aims to visualize and analyze the characteristics of these cells and their interactions with other cells in the body. This understanding could lead to better treatments for age-related diseases and improve the effectiveness of therapies like chemotherapy and radiation. Patients may benefit from insights gained about how to manage or prevent conditions linked to cellular aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults or individuals undergoing chemotherapy or radiation treatment who may experience complications related to cellular aging.
Not a fit: Patients with acute conditions unrelated to aging or cellular senescence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and improving recovery from cancer therapies.
How similar studies have performed: Other research has shown promising results in understanding cellular senescence and its implications for health, indicating that this approach has potential for significant advancements.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Neretti, Nicola — Brown University
- Study coordinator: Neretti, Nicola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.