Mapping the electrochemical interactions between cell organelles
Intracellular Electrophysiology: An electrochemical atlas of organelles
This study is exploring how tiny parts of our cells, called organelles, work together and communicate, especially in diseases that affect the brain, to find new ways to help restore their normal function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10895574 on NIH RePORTER |
What this research studies
This research aims to create an electrochemical atlas of organelles to understand how they communicate and interact, particularly in the context of neurodegenerative diseases. By studying the connections between organelles, the research seeks to identify how these interactions can be manipulated to restore normal cellular function. The approach involves examining the electrochemical states of organelles and how they influence processes like lipid metabolism and apoptosis. This could lead to new insights into treating diseases caused by dysfunctional organelle contacts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative disorders that may be linked to dysfunctional organelle interactions.
Not a fit: Patients with acute injuries or conditions unrelated to neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies for neurodegenerative diseases by restoring normal organelle function.
How similar studies have performed: While the concept of inter-organelle communication is emerging, this specific approach to mapping electrochemical interactions is relatively novel and has not been extensively tested.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Krishnan, Yamuna — University of Chicago
- Study coordinator: Krishnan, Yamuna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.