Mapping the effects of amyloid deposits in the aging brain
Official title: Project 3: 3-D Molecular Atlas of cerebral amyloid angiopathy in the aging brain with and without co-pathology
Funded at Columbia University Health Sciences · NIH-10935941 · Data updated 2026-11-12
This study is looking at how cerebral amyloid angiopathy (CAA), a condition that often comes with aging, affects brain cells and their environment, especially in relation to Alzheimer's disease, to help us better understand these conditions and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $504,727 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935941 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have been diagnosed with Alzheimer's disease or exhibit symptoms of cognitive decline.
✕Less likely to help
Patients without any signs of cognitive impairment or those who are not elderly may not benefit from this research.
What this research studies
This research investigates how cerebral amyloid angiopathy (CAA), a condition associated with aging, affects the brain's cellular environment in specific regions. By examining post-mortem human brain tissue, the study aims to create a detailed 3-D molecular atlas that highlights the interactions between CAA and Alzheimer's disease pathology. The researchers will analyze how CAA influences the composition and function of brain cells, potentially leading to cognitive decline. This work seeks to enhance our understanding of the relationship between CAA and Alzheimer's disease, which could inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating cognitive decline associated with Alzheimer's disease and CAA.
How similar studies have gone: Previous research has shown promising results in understanding the effects of amyloid deposits on brain function, but this specific approach of creating a 3-D molecular atlas is relatively novel.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Schneider, Julie a. — Columbia University Health Sciences
- Study coordinator: Schneider, Julie a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.