Mapping the diverse cell types in the human brain
Official title: Spatial genomics and cell atlas of the human brain
Funded at Harvard University · NIH-11042223 · Data updated 2026-11-12
This study is looking at the different types of cells in the human brain and how they work together, using a special imaging technique to better understand brain function and diseases, especially as we age, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | February 22, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $763,579 |
| NIH project number | 5R01MH134800-02 |
| Project ID | NIH-11042223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurological conditions or those interested in the effects of aging on brain health.
✕Less likely to help
Patients with acute brain injuries or those not experiencing age-related cognitive decline may not benefit from this research.
What this research studies
This research investigates the complex cellular diversity of the human brain and how different cell types interact with each other. Using an advanced technique called MERFISH, the study aims to improve the speed and accuracy of imaging brain cells in three dimensions. By identifying and mapping these cells, especially in the aging brain, the research seeks to uncover the molecular mechanisms that underlie brain function and disorders. Patients may benefit from insights gained about brain diseases and aging-related changes in brain structure and function.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of brain diseases and aging, potentially informing new treatments.
How similar studies have gone: Previous research using similar spatial genomics techniques has shown promise in mapping cellular interactions in other tissues, suggesting potential success in this novel application to the human brain.
Where this research is happening
-
Harvard University
Cambridge, United States Active
Researchers
- Principal investigator: Zhuang, Xiaowei — Harvard University
- Study coordinator: Zhuang, Xiaowei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.