Mapping the different types of norepinephrine and serotonin neurons in the brain
Official title: Structure-function cell atlas for norepinephrine and serotonin neurons
Funded at Allen Institute · NIH-11060931 · Data updated 2026-11-12
This study is looking at different types of brain cells that use norepinephrine and serotonin, which are important for how we think and act, to help us understand how they affect our choices and behaviors, and this could lead to better treatments for mood disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | March 22, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,442,157 |
| NIH project number | 5R01MH134833-02 |
| Project ID | NIH-11060931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with mood disorders or conditions influenced by serotonin and norepinephrine systems.
✕Less likely to help
Patients with conditions unrelated to neurotransmitter function or those not affected by serotonin or norepinephrine may not receive benefits from this research.
What this research studies
This research investigates the various subclasses of norepinephrine (NE) and serotonin (5-HT) neurons, which are crucial for brain function and behavior. By conducting molecular, genetic, anatomical, physiological, and behavioral experiments in mice, the study aims to uncover the distinct properties and functions of these neuron subclasses. The findings could lead to a better understanding of how these neurons influence decision-making and behavior, potentially paving the way for targeted therapies. Patients may benefit from insights gained about neurotransmitter systems that could inform treatment strategies for mood disorders and other conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of neurotransmitter systems, leading to improved treatments for mood disorders and other related conditions.
How similar studies have gone: Previous research has shown promise in understanding neurotransmitter systems, but this approach to classifying neuron subclasses is relatively novel and untested.
Where this research is happening
-
Allen Institute
Seattle, United States Active
Researchers
- Principal investigator: Cohen, Jeremiah Yaacov — Allen Institute
- Study coordinator: Cohen, Jeremiah Yaacov
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.