Mapping the development of the mouse brain at a cellular level
Comprehensive single-cell atlas of the developing mouse brain
This study is all about mapping how the mouse brain develops, which can help us learn more about how different brain cells are formed, and it’s aimed at anyone interested in understanding brain growth and development better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10877847 on NIH RePORTER |
What this research studies
This research aims to create a detailed atlas of the developing mouse brain, which serves as a crucial model for understanding how different cell types in the mammalian brain originate. By using advanced techniques like single-cell RNA sequencing and ATAC sequencing, the researchers will analyze brain development from early embryonic stages to postnatal periods. This comprehensive approach will help identify the lineage relationships between developing and adult brain cells, providing insights into neurodevelopmental processes. The findings could enhance our understanding of brain evolution and cell classification.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals interested in neurodevelopmental conditions or those with a family history of such disorders.
Not a fit: Patients with fully developed brains or those outside the age range of 21 years and older may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding neurodevelopmental disorders and brain evolution.
How similar studies have performed: Other research has successfully utilized similar multi-omic approaches to map brain development, indicating a promising avenue for this study.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Arlotta, Paola — Harvard University
- Study coordinator: Arlotta, Paola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.