Mapping the development of the lower urinary tract at the cellular level
The single and same cell 3D atlas of epigenome and transcriptome of the lower urinary tract
['FUNDING_U01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10899539
This study is working on making a detailed 3D map of how the lower urinary tract, like the bladder and urethra, develops from a single organ, which could help us understand and find the causes of certain birth defects related to this area.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10899539 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a detailed 3D map of the lower urinary tract by analyzing individual cells' genetic and epigenetic information. It aims to visualize how the urinary tract develops from a single organ into distinct structures, such as the bladder and urethra. By employing advanced technologies like single-cell Multi-omics and Spatial Transcriptome, the project will generate comprehensive digital libraries that catalog the unique characteristics of each cell type involved in this process. This information could help identify the causes of complex birth defects related to urinary tract development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities of the urinary tract or those interested in the genetic basis of such conditions.
Not a fit: Patients without congenital urinary tract defects or those not affected by related developmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of congenital urinary tract defects.
How similar studies have performed: Other research has shown promise in using similar multi-omics approaches to understand complex developmental processes, indicating potential for success in this area.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, XUE SEAN — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: LI, XUE SEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.